SERRAFX contains only pure, potent Serratiopeptidase. Each capsule contains the clinically recommended 500 mg of pure Serratiopeptidase and is assayed to 120,000 fibrinolytic units per gram (compared to other brands at 30,000-40,000 units). What is Serratiopeptidase? Serratiopeptidase is a proteolytic enzyme that contains a peptidase originally found in the gut of the Japanese silkworm and now isolated from the bacteria strain, Serratia sp. HY-6. Scientific literature and controlled clinical trials with significant patient groups suggest that serratiopeptidase appears to be efficacious in the reduction of certain types of inflammation and swelling, while also enhancing the action of certain antibiotics. Mechanism of Action Studies suggest that Serratiopeptidase is involved in the degradation of inflammatory mediators, proteolytic modification of cell-surface adhesion molecules that guide inflammatory cells to their targets, suppression of edema, reduction of immune complexes and activation of fibrinolysis. (Klein, G, Kullich W. Short-term treatment of painful osteoarthritis of the knee with oral enzymes. A randomized, double-blind study versus diclofenac. Clin. Drug Invest. 2000. 19(1), 15-23. It is also believed that Serratiopeptidase reduces inflammation through three distinct processes: 1) degrades insoluble protein by-products of fibrin 2) thins fluids involved in inflammation or injury, and facilitates drainage 3) reduces discomfort by inhibiting the release of pain-inducing amines called bradykin (Rothschild, J. Clinical use of Serrapeptase; an alternative to Non-steroidal anti-inflammatory agents, The American Chiropractor, 1991, p17.; Esch PM, Gemgross H. Fabian A, Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with Serrapeptase-a prospective study (German). Fortschr. Med. 1989. 107 (4), 67-8, 71-2.; Yamasaki H, Tsuji H, Saeki K. Anti-inflammatory action of a protease, TSP, produced by Serratia. Nippon Yakurigaku Zasshi. 1967. 63(4), 302-14. |